Introduction Advantages Applications Business Model More Info

Fluorescent Site-Specific Integration
Cell Line Development Platform

Fast to Obtain RCB in 1.5 Months Fast to Know Product Qualities in 1 Month

Double Fast

    • Fast to Obtain RCB 1.5 Months

    Site-specific integrated hot spot


    Uniformed cell pool

    • Fast to Know Product Qualities 1 Month

    Titer - 8 to 15 g/L


    Quality - 80% correct pairing rate for BsAbs

    AlfaCell Re-defines Cell Line Development

    Pain Points Site-specific Integration Platform Transposon System

    Random Insertion

    (CHO-K1 WT and CHO-GS)

    Titer 4-16 g/L 3-5 g/L 2-5 g/L
    Timeline

    1.5 months

    (due to green protein application)

    		> 6 months > 6 months
    Stability Pre-selected single stable site Unpredictable due to multi-sites Unpredictable due to random insertion
    Workload Screened with 1-2 of 96-well plates Screened with 50-100 of 96-well plates Screened with 50-100 of 96-well plates
    Product Quality Evaluation Able to evaluate product qualities from homogenized cell pool within 1 month post transfection Unable to evaluate product qualities until RCB available (within 3-4 months) Unable to evaluate product qualities until RCB available (within 3-4 months)
    Advantages
    Core Competitiveness Differentiation

    • Site-specific “hot spot” – high titer/stable site (4–16 g/L)

    • Shorten development timeline (1.5 months to RCB)

    • Product quality evaluation available in early stage (in 1 month)

    Competitive Barriers

    • Benefit to reduction of IND filing timeline

    • Early stage development application available

    • Broad application in BsAb and ADC

    Patent

    • Patent matrix to protect technology platform

    • FTO cleared in US/China

    Commercialization

    • 1st commercial site-specific integration technology available for the global industry

    • Completion of 50+ projects in 1.5 years

    • Success delivery rate: 89%

    Technological Leadership

    • Non-academia algorithm research

    • Pain point-oriented total solution

    Technical Difficulties

    • Integration of innovative platforms to form a core competitive ecosystem

    Other Platform Model

    • Random insertion (CHO-K1/CHO-GS): low titer, long timeline, massive workload

    • Transposon system: high titer, long timeline, high workload